Peptide index
331 compounds across 19classes. Each one carries an evidence tier, because “there are studies” means something very different for semaglutide than it does for most of this list.
18 compounds
5-Amino-1MQ
Animal data onlyA small-molecule NNMT inhibitor that raises intracellular NAD+ in fat cells and pushes them toward burning energy rather than storing it - popular precisely because it is an oral capsule.
Body Composition, Anabolic & Performance
ACE-031
Human trialsA decoy activin receptor fused to an antibody Fc that soaks up myostatin and its relatives, producing rapid lean mass gain - and the vascular side effects that killed its clinical programme.
Body Composition, Anabolic & Performance
AICAR
Human trialsAn AMPK-activating nucleoside that mimics the cellular energy-deficit signal of exercise - the original 'exercise in a pill', and one of the first compounds WADA banned for that reason.
Body Composition, Anabolic & Performance
Apitegromab
Human RCTA highly selective antibody that blocks myostatin before it is activated, developed for spinal muscular atrophy and now being tested to protect muscle during GLP-1 weight loss.
Body Composition, Anabolic & Performance
Bimagrumab
Human RCTA monoclonal antibody that blocks activin type II receptors, simultaneously adding lean mass and stripping fat mass - now being developed mainly to stop GLP-1 users from losing muscle.
Body Composition, Anabolic & Performance
Follistatin-315
Animal data onlyThe mature circulating form of follistatin, with lower affinity for cell-surface heparan sulfate than FST-288 and therefore more systemic distribution.
Body Composition, Anabolic & Performance
Follistatin-344
Animal data onlyA myostatin- and activin-binding glycoprotein that removes the brake on muscle growth - and the most heavily counterfeited product in the peptide market.
Body Composition, Anabolic & Performance
Hexarelin (performance use)
Human trialsThe most potent of the classic GH-releasing hexapeptides, used in performance contexts as much for its CD36-mediated cardiac effects as for the growth hormone spike.
Body Composition, Anabolic & Performance
IGF-1 DES
Animal data onlyA truncated IGF-1 that is roughly ten times more potent locally but clears in minutes, which is why it is injected directly into the muscle you just trained.
Body Composition, Anabolic & Performance
IGF-1 LR3
Animal data onlyAn engineered insulin-like growth factor 1 analogue that dodges its binding proteins, so it stays active far longer than natural IGF-1 and is used to push hypertrophy and tissue repair.
Body Composition, Anabolic & Performance
IGF-1 LR3 + GH stack
AnecdotalThe canonical advanced hypertrophy protocol - recombinant GH or a secretagogue driving the axis from above while long-acting IGF-1 supplies the effector below - and also the fastest route to a hypoglycaemic emergency in this category.
Body Composition, Anabolic & Performance
Mecasermin
Approved drugThe only FDA-approved recombinant IGF-1, licensed for severe primary IGF-1 deficiency in children and the reference point against which every grey-market IGF analogue should be judged.
Body Composition, Anabolic & Performance
MGF
Animal data onlyThe 24-amino-acid tail of an exercise-induced IGF-1 splice variant, injected locally on the theory that it wakes up satellite cells for repair and growth.
Body Composition, Anabolic & Performance
Myostatin (GDF-8)
Animal data onlyThe body's own brake on muscle growth - not something anyone takes, but the target that half this category is built to switch off.
Body Composition, Anabolic & Performance
PEG-MGF
AnecdotalMGF with a polyethylene glycol chain bolted on so it survives in circulation for days instead of minutes, traded for the loss of any local-only action.
Body Composition, Anabolic & Performance
SLU-PP-332
Animal data onlyA pan-estrogen-related-receptor agonist that reproduces several endurance-training adaptations in mouse muscle without the training - the current front-runner for 'exercise in a bottle'.
Body Composition, Anabolic & Performance
Tesamorelin (visceral fat use)
Approved drugThe only compound with prospective randomised evidence that it selectively strips visceral abdominal fat, and the closest thing this category has to a proven drug.
Body Composition, Anabolic & Performance
Trevogrumab
Human RCTRegeneron's anti-myostatin antibody, being combined with semaglutide to make weight loss come from fat rather than muscle.
Body Composition, Anabolic & Performance