Peptide index

A once-weekly GLP-2 analogue that hit its phase 3 endpoint in short bowel syndrome and would replace daily teduglutide injections — if the FDA had not asked for another trial first.

Gut & Gastrointestinal

A stable fragment of a protein found in gastric juice, originally developed as an inflammatory bowel disease drug, that people take orally to try to heal ulcers, leaky gut and NSAID-induced stomach damage.

Gut & Gastrointestinal

Oral immunoglobulin and growth-factor fractions from bovine colostrum, taken in gram quantities to bind gut antigens and support mucosal barrier repair — the most accessible and best-tolerated thing in this category.

Gut & Gastrointestinal

Zealand Pharma's twice-weekly GLP-2 analogue for short bowel syndrome, delivered by autoinjector — it worked in phase 3 but got a Complete Response Letter and is now repeating the trial.

Gut & Gastrointestinal

The three-amino-acid business end of alpha-MSH, taken orally to shut down NF-kB-driven inflammation directly in the colon without the tanning or libido effects of the parent hormone.

Gut & Gastrointestinal

An oral octapeptide that tightens intestinal tight junctions by blocking zonulin signalling — the most clinically advanced 'leaky gut' drug ever developed, and it failed its phase 3 in coeliac disease.

Gut & Gastrointestinal

An orally active 14-amino-acid peptide capsule approved for IBS-C and chronic constipation that pulls fluid into the gut lumen and simultaneously turns down visceral pain signalling.

Gut & Gastrointestinal

The hormone that fires the stomach's housekeeping contractions between meals, and the drug class built to mimic it for gastroparesis — where erythromycin remains the only agent that actually reached the clinic.

Gut & Gastrointestinal

An approved once-daily oral peptide for chronic constipation and IBS-C that copies the body's own uroguanylin, switching on only in the acidic upper small intestine and causing somewhat less diarrhoea than linaclotide.

Gut & Gastrointestinal

A research class of orally delivered antimicrobial peptides intended to reshape the gut microbiome the way rifaximin does — killing selectively in the lumen with essentially no systemic absorption.

Gut & Gastrointestinal

The first hormone ever discovered, now used as an FDA-approved intravenous diagnostic that makes the pancreas dump bicarbonate on command so radiologists and endoscopists can see how it is working.

Gut & Gastrointestinal

An FDA-approved intravenous cholecystokinin fragment that forces the gallbladder to contract on demand, used to measure gallbladder ejection fraction and to test pancreatic enzyme output.

Gut & Gastrointestinal

An FDA-approved daily injection that makes the remaining small bowel physically grow taller villi and absorb more, letting short bowel syndrome patients cut back on IV nutrition.

Gut & Gastrointestinal

The body's own intestinal peptides that control fluid secretion and, unexpectedly, gut-to-brain satiety signalling — the natural templates that plecanatide and linaclotide were built from.

Gut & Gastrointestinal