Peptide index
331 compounds across 19classes. Each one carries an evidence tier, because “there are studies” means something very different for semaglutide than it does for most of this list.
15 compounds
Alpha-MSH
Animal data onlyThe natural thirteen-amino-acid melanocortin that shuts down NF-kB-driven inflammation across nearly every tissue, and the parent molecule of both KPV and the melanotans.
Immune, Thymic & Anti-Inflammatory
Anakinra
Approved drugA recombinant interleukin-1 receptor antagonist injected daily that blocks IL-1 signalling outright, used in rheumatoid arthritis, Still's disease and the autoinflammatory syndromes.
Immune, Thymic & Anti-Inflammatory
Colostrinin
Human RCTA proline-rich polypeptide complex from colostrum, taken sublingually, that modulates cytokine balance and has been trialled in mild Alzheimer's disease with modest results.
Immune, Thymic & Anti-Inflammatory
Crystagen
AnecdotalA Khavinson tripeptide bioregulator marketed for thymic and immune support, taken as short oral courses a few times a year.
Immune, Thymic & Anti-Inflammatory
Cyclosporine A
Approved drugThe archetypal peptide immunosuppressant - a cyclic eleven-residue fungal peptide that shuts down T-cell activation and made organ transplantation routine.
Immune, Thymic & Anti-Inflammatory
Defensins
In vitro onlyThe cationic host-defence peptide family that punches holes in microbial membranes and simultaneously recruits immune cells - a template class for drug design rather than a single purchasable compound.
Immune, Thymic & Anti-Inflammatory
Interferon-adjacent peptide mimetics
In vitro onlyShort peptides designed to reproduce the useful part of interferon signalling without the systemic toxicity of the full cytokine - still firmly at the research stage.
Immune, Thymic & Anti-Inflammatory
Lactoferrin
Human RCTAn iron-binding glycoprotein from milk and mucosal secretions that starves bacteria of iron, disrupts viral entry and tunes mucosal immunity - the most widely used oral immune peptide there is.
Immune, Thymic & Anti-Inflammatory
Pidotimod
Human RCTA synthetic dipeptide-like immunostimulant taken orally, used in Italy, China and Latin America to cut the frequency of recurrent respiratory infections in children.
Immune, Thymic & Anti-Inflammatory
Thymogen
ObservationalA synthetic Glu-Trp dipeptide registered as an immunostimulant in Russia, representing the minimal active core of thymic immune signalling.
Immune, Thymic & Anti-Inflammatory
Thymopentin
Human trialsThe five-amino-acid active fragment of thymopoietin, used clinically in parts of Europe and Asia to restore T-cell function in immunodeficiency, hepatitis B and rheumatoid arthritis.
Immune, Thymic & Anti-Inflammatory
Thymosin Alpha-1
Human RCTA 28-amino-acid thymic peptide, approved in dozens of countries outside the US, that pushes immature T-cells toward mature Th1 function and is used for chronic hepatitis, immunosenescence and immune-suppressed states.
Immune, Thymic & Anti-Inflammatory
Thymulin
Animal data onlyA zinc-dependent thymic nonapeptide that regulates T-cell differentiation and, at low doses, has surprisingly strong anti-inflammatory and analgesic effects in animal models.
Immune, Thymic & Anti-Inflammatory
Tuftsin
Animal data onlyAn IgG-derived tetrapeptide that switches macrophages and microglia toward active phagocytosis, and the structural parent of the anxiolytic peptide Selank.
Immune, Thymic & Anti-Inflammatory
Voclosporin
Approved drugA next-generation cyclosporine analogue approved for lupus nephritis, with more potent calcineurin inhibition and predictable enough pharmacokinetics to be dosed without blood-level monitoring.
Immune, Thymic & Anti-Inflammatory