Peptide index
331 compounds across 19classes. Each one carries an evidence tier, because “there are studies” means something very different for semaglutide than it does for most of this list.
8 compounds
CRF antagonist peptides
Animal data onlyA family of peptide blockers of the body's master stress hormone, used in the lab to shut down CRF signalling and studied for stress-driven anxiety, depression, gut dysfunction and insomnia.
Sleep, Circadian & Mood
DSIP
Human trialsA nine-amino-acid peptide first pulled out of rabbit brain blood in the 1970s that people inject before bed to deepen slow-wave sleep and fall asleep faster.
Sleep, Circadian & Mood
Epitalon (circadian use)
Human trialsA four-amino-acid pineal peptide taken in short annual courses to pull a flattened, age-related melatonin rhythm back into a normal night-time peak.
Sleep, Circadian & Mood
Melanin-concentrating hormone
Animal data onlyA hypothalamic neuropeptide that switches on during REM sleep and simultaneously drives eating — which is exactly why the drug industry has spent twenty years trying to block it rather than give it.
Sleep, Circadian & Mood
Neuropeptide S (mood/arousal)
Animal data onlyA twenty-amino-acid neuropeptide that does something almost nothing else does in rodents — increases wakefulness and arousal while simultaneously reducing anxiety instead of raising it.
Sleep, Circadian & Mood
Orexin-A (wake use)
Human trialsThe hypothalamic peptide that holds you awake, delivered intranasally as an alertness rescue after sleep loss and studied as a replacement therapy in narcolepsy type 1.
Sleep, Circadian & Mood
Pinealon (circadian use)
Animal data onlyA three-amino-acid Khavinson bioregulator run alongside Epitalon in Russian protocols, aimed at neuronal protection and at keeping sleep and cognitive rhythm intact with age.
Sleep, Circadian & Mood
Selank (anxiolytic use)
Human trialsA nasal anxiolytic peptide registered as a medicine in Russia that takes the edge off anxious arousal without sedating you, which is why it often improves sleep as a side effect rather than as a direct hypnotic action.
Sleep, Circadian & Mood