Peptide index

The protective counter-arm of the renin-angiotensin system, a short peptide that opposes fibrosis, inflammation and vasoconstriction rather than driving them.

Cardiometabolic, Vascular & Renal

Synthetic human angiotensin II used as a rescue vasopressor drip when noradrenaline and vasopressin are not holding blood pressure up in septic or distributive shock.

Cardiometabolic, Vascular & Renal

An endogenous peptide that makes the heart contract harder while dilating blood vessels, a rare combination that has made it a long-standing heart failure research target.

Cardiometabolic, Vascular & Renal

A hirudin-derived direct thrombin inhibitor given as an IV drip during angioplasty and stenting, mainly when heparin cannot be used.

Cardiometabolic, Vascular & Renal

Recombinant atrial natriuretic peptide, approved only in Japan, infused to vasodilate and offload the heart in acute heart failure.

Cardiometabolic, Vascular & Renal

A designer natriuretic peptide fusing C-type and mamba-venom peptides, built to unload the heart and protect the kidney without dropping blood pressure as hard as BNP does.

Cardiometabolic, Vascular & Renal

A recombinant leech-derived thrombin inhibitor injected under the skin to prevent deep vein thrombosis after hip replacement, now largely off the market.

Cardiometabolic, Vascular & Renal

A recombinant kallikrein inhibitor injected to abort hereditary angioedema attacks upstream of bradykinin, but with a real anaphylaxis risk that keeps it clinician-administered.

Cardiometabolic, Vascular & Renal

The first PCSK9 inhibitor you can swallow - a once-daily oral macrocyclic peptide that cuts LDL cholesterol by roughly half, matching injectable antibodies.

Cardiometabolic, Vascular & Renal

A snake-venom-derived cyclic peptide drip that blocks the final common step of platelet clumping during heart attacks and stenting.

Cardiometabolic, Vascular & Renal

A self-injected decapeptide that shuts off a hereditary angioedema attack by blocking the bradykinin receptor driving the swelling.

Cardiometabolic, Vascular & Renal

A recombinant hirudin drip that was the reference treatment for heparin-induced thrombocytopenia before it was withdrawn from the market.

Cardiometabolic, Vascular & Renal

Recombinant human BNP given as an IV drip to drop filling pressures and relieve breathlessness in acute decompensated heart failure - effective on haemodynamics but not on outcomes.

Cardiometabolic, Vascular & Renal

A pegylated cyclic peptide that blocks complement C3, controlling paroxysmal nocturnal haemoglobinuria systemically and slowing geographic atrophy when injected into the eye.

Cardiometabolic, Vascular & Renal

A weekly injected hepcidin mimetic that locks iron away from red cell production, keeping haematocrit under control in polycythaemia vera without repeated phlebotomy.

Cardiometabolic, Vascular & Renal

Recombinant human relaxin, the pregnancy hormone that widens blood vessels and boosts renal blood flow, trialled as a 48-hour infusion in acute heart failure and ultimately unsuccessful.

Cardiometabolic, Vascular & Renal

A once-daily self-injected macrocyclic peptide that blocks complement C5, giving myasthenia gravis patients an alternative to monthly infusion antibodies.

Cardiometabolic, Vascular & Renal