Peptide index
331 compounds across 19classes. Each one carries an evidence tier, because “there are studies” means something very different for semaglutide than it does for most of this list.
26 compounds
AHK-Cu
In vitro onlyGHK-Cu's less-famous cousin, used almost entirely in scalp serums to push VEGF from dermal papilla cells and improve follicle blood supply.
Cosmetic, Skin & Hair
Argireline
Human trialsA SNAP-25 mimic applied to the skin to blunt micro-contractions in expression lines — real but modest, and nothing like an injection of botulinum toxin.
Cosmetic, Skin & Hair
Biotinoyl Tripeptide-1
ObservationalGHK with a biotin group attached, used in scalp serums to strengthen the follicle's anchoring in the dermis and reduce hair fall.
Cosmetic, Skin & Hair
Botulinum toxin type A
Approved drugThe bacterial neurotoxin that actually paralyses mimetic muscle — not a peptide in any useful sense, but the benchmark every topical 'peptide Botox' is measured against and loses to.
Cosmetic, Skin & Hair
Capixyl
ObservationalA hair complex pairing a matrix-strengthening tetrapeptide with a red clover isoflavone that inhibits 5-alpha-reductase, attacking both the follicle's anchoring and its DHT exposure.
Cosmetic, Skin & Hair
Decapeptide-12
Human trialsA non-cytotoxic tyrosinase inhibitor developed as a hydroquinone alternative, with real published melasma data behind it — unusual for this category.
Cosmetic, Skin & Hair
Eyeseryl
ObservationalAn anti-puffiness tetrapeptide for under-eye bags that works on fluid retention and capillary leak rather than on wrinkles or pigment.
Cosmetic, Skin & Hair
GHK-Cu (topical)
Human trialsThe best-evidenced cosmetic peptide there is: a copper-carrying tripeptide that pushes fibroblasts to rebuild collagen, elastin and glycosaminoglycans while dialling down matrix breakdown.
Cosmetic, Skin & Hair
Haloxyl
ObservationalA four-part complex for dark circles that chelates leaked iron, speeds bilirubin clearance and thickens the thin under-eye skin that lets the pigment show through.
Cosmetic, Skin & Hair
Hexapeptide-11
In vitro onlyA yeast-fermentation-derived hexapeptide marketed as an anti-senescence active for dermal firmness rather than as a wrinkle-specific ingredient.
Cosmetic, Skin & Hair
Leuphasyl
In vitro onlyA leu-enkephalin analogue applied topically to quiet acetylcholine release from the nerve side of the junction, sold as the presynaptic partner to Argireline.
Cosmetic, Skin & Hair
Matrixyl
Human RCTA fatty-acid-tagged collagen fragment that tricks fibroblasts into thinking the matrix has been damaged, so they lay down new collagen and fibronectin.
Cosmetic, Skin & Hair
Matrixyl 3000
ObservationalTwo matrikine lipopeptides sold as one ingredient: one rebuilds matrix, the other suppresses the inflammatory and glycation damage that tears it down.
Cosmetic, Skin & Hair
Matrixyl Synthe'6
ObservationalA lipopeptide marketed for deeper set wrinkles because it stimulates six matrix constituents at once, including the basement-membrane proteins the other Matrixyls ignore.
Cosmetic, Skin & Hair
Melanostatine-5
In vitro onlyA competitive alpha-MSH blocker that shuts down the signal telling melanocytes to make pigment, rather than poisoning the tyrosinase enzyme downstream.
Cosmetic, Skin & Hair
Melitane
In vitro onlyThe mirror image of Melanostatine: an alpha-MSH mimic that switches MC1R on to deepen pigment and improve the skin's own UV defence, without an injection.
Cosmetic, Skin & Hair
Palmitoyl Tripeptide-1
In vitro onlyGHK with a fatty tail bolted on so it actually penetrates the stratum corneum — copper-peptide-style collagen signalling without the copper or the blue stain.
Cosmetic, Skin & Hair
Progeline
ObservationalA tripeptide aimed at sagging rather than wrinkles, marketed for reducing progerin and inhibiting the elastase that dissolves the skin's elastic scaffold.
Cosmetic, Skin & Hair
PTD-DBM
Animal data onlyA cell-penetrating peptide that pries the Wnt brake CXXC5 off Dishevelled, restarting follicle neogenesis in mouse skin — currently the most interesting preclinical hair compound in the peptide world.
Cosmetic, Skin & Hair
SNAP-8
ObservationalA longer Argireline with two extra residues that bind the SNARE complex more tightly, usually formulated alongside its shorter parent.
Cosmetic, Skin & Hair
Syn-Ake
In vitro onlyA synthetic mimic of temple viper venom that blocks the muscle-type nicotinic acetylcholine receptor, working on the receiving side of the junction instead of the nerve side.
Cosmetic, Skin & Hair
Syn-Coll
In vitro onlyA thrombospondin-1 mimic that converts latent TGF-beta into its active form, driving collagen synthesis through the body's own wound-repair switch.
Cosmetic, Skin & Hair
Thymosin Beta-4 (cosmetic)
Animal data onlyThe actin-sequestering repair peptide applied to skin and scalp rather than injected, on the strength of mouse data showing it activates hair follicle stem cells.
Cosmetic, Skin & Hair
Tripeptide-1
In vitro onlyGHK without the copper — used when copper's blue colour or its reaction with vitamin C and other reducing actives would wreck the formula.
Cosmetic, Skin & Hair
Vialox
In vitro onlyA curare-style competitive blocker at the muscle nicotinic receptor, sold for fast surface smoothing rather than long-term collagen change.
Cosmetic, Skin & Hair
Zinc Thymulin
Human trialsA zinc-activated thymic nonapeptide applied to the scalp, and one of the very few experimental hair peptides that has actually been tested on human heads.
Cosmetic, Skin & Hair