Peptide index

A PTH-related-protein analogue that builds bone as fast as teriparatide with less hypercalcaemia, used for osteoporosis at very high fracture risk.

Clinical Endocrine & Hormone Analogues

An oxytocin receptor blocker infused to hold off preterm labour for a couple of days, long enough to give steroids and move the mother to a unit with a neonatal ICU.

Clinical Endocrine & Hormone Analogues

A salmon-derived calcium-lowering hormone used for Paget's disease, acute hypercalcaemia and the pain of recent osteoporotic vertebral fracture, now largely displaced by better drugs.

Clinical Endocrine & Hormone Analogues

A long-acting oxytocin analogue given as a single shot after delivery to clamp the uterus down and prevent postpartum haemorrhage, in a heat-stable form that survives without refrigeration.

Clinical Endocrine & Hormone Analogues

A slow-release porcine ACTH gel that drives the adrenals to make cortisol, still used for infantile spasms, MS relapses and steroid-refractory autoimmune disease at an extraordinary price.

Clinical Endocrine & Hormone Analogues

The synthetic first 24 residues of ACTH, injected as a single dose to see whether the adrenal glands can still make cortisol.

Clinical Endocrine & Hormone Analogues

A vasopressin analogue stripped of blood-pressure effects that concentrates urine, and which at higher doses also dumps stored von Willebrand factor to stop bleeding.

Clinical Endocrine & Hormone Analogues

A D-amino-acid peptide calcimimetic pushed straight into the dialysis line three times a week to bring down parathyroid hormone in kidney failure, without the nausea that sinks oral cinacalcet.

Clinical Endocrine & Hormone Analogues

A grab-bag of peptides given not to treat anything but to provoke a gland and see whether it responds, which is how growth hormone deficiency, Cushing's and gastrinoma get diagnosed.

Clinical Endocrine & Hormone Analogues

Eli Lilly's once-weekly basal insulin, a single-chain insulin fused to an antibody Fc fragment, giving an unusually flat profile across the whole week.

Clinical Endocrine & Hormone Analogues

A basal insulin re-engineered to cling to albumin for a full week, so one injection replaces seven and total annual injections drop from about 365 to 52.

Clinical Endocrine & Hormone Analogues

A long-acting somatostatin analogue given as a deep subcutaneous gel every four weeks for acromegaly and for slowing gastroenteropancreatic neuroendocrine tumours.

Clinical Endocrine & Hormone Analogues

The original somatostatin analogue, used since 1988 to shut down excess growth hormone in acromegaly and to control the flushing and diarrhoea of carcinoid syndrome and VIPoma.

Clinical Endocrine & Hormone Analogues

The uterine contraction hormone, infused to induce or strengthen labour and pushed after delivery to clamp the uterus shut and stop postpartum bleeding.

Clinical Endocrine & Hormone Analogues

A once-daily PTH prodrug that drips out parathyroid hormone continuously, replacing the missing hormone in chronic hypoparathyroidism instead of just propping up calcium with pills.

Clinical Endocrine & Hormone Analogues

A broad-spectrum somatostatin analogue with unusually strong SSTR5 binding, approved for Cushing's disease and for acromegaly that octreotide and lanreotide failed to control.

Clinical Endocrine & Hormone Analogues

A mutated growth hormone molecule that jams the GH receptor instead of activating it, normalising IGF-1 in acromegaly that somatostatin analogues could not control.

Clinical Endocrine & Hormone Analogues

Full-length recombinant parathyroid hormone, the first true replacement therapy for chronic hypoparathyroidism, withdrawn worldwide at the end of 2024 but still the reference agent for the indication.

Clinical Endocrine & Hormone Analogues

An MC4R agonist that restores the broken satiety signal in people whose obesity comes from hypothalamic damage or a specific genetic defect, rather than from ordinary energy balance.

Clinical Endocrine & Hormone Analogues

The endogenous inhibitory hormone that every somatostatin analogue is copying, used itself only as a short intravenous infusion for acute variceal or pancreatic bleeding because it is destroyed within minutes.

Clinical Endocrine & Hormone Analogues

The active fragment of parathyroid hormone which, given as one short daily spike, actually builds new bone instead of just slowing its loss.

Clinical Endocrine & Hormone Analogues

A slow-release vasopressin prodrug that constricts the splanchnic circulation, used to improve kidney function in hepatorenal syndrome and to stop variceal bleeding in cirrhosis.

Clinical Endocrine & Hormone Analogues

The only FDA-approved GHRH analogue for a body-composition indication, given daily to strip visceral abdominal fat in people with HIV-associated lipodystrophy.

Clinical Endocrine & Hormone Analogues

Recombinant TSH that wakes up thyroid tissue for thyroglobulin testing and radioiodine treatment, so thyroid cancer patients no longer have to become hypothyroid to be scanned.

Clinical Endocrine & Hormone Analogues

The native antidiuretic hormone, used in intensive care as a catecholamine-sparing vasopressor that raises blood pressure in septic and vasodilatory shock.

Clinical Endocrine & Hormone Analogues

A C-type natriuretic peptide analogue injected daily in children with achondroplasia to release the brake that the FGFR3 mutation puts on the growth plate.

Clinical Endocrine & Hormone Analogues