Peptide index
331 compounds across 19classes. Each one carries an evidence tier, because “there are studies” means something very different for semaglutide than it does for most of this list.
21 compounds
Anamorelin
Approved drugAn oral ghrelin-receptor agonist approved in Japan for cancer cachexia, which reliably increases appetite, body weight and lean mass but has never shown a matching improvement in strength or survival.
Growth Hormone Secretagogues & GHRH Analogues
AOD-9604
Human RCTA modified C-terminal fragment of growth hormone marketed for fat loss without GH's effects on blood sugar or IGF-1, which is true - but the human weight-loss data is essentially negative.
Growth Hormone Secretagogues & GHRH Analogues
CJC-1295 with DAC
Human trialsA GHRH analogue carrying a maleimide linker that binds covalently to serum albumin, converting a 30-minute peptide into one that raises GH and IGF-1 for the better part of a week.
Growth Hormone Secretagogues & GHRH Analogues
CJC-1295 without DAC
AnecdotalA short-acting GHRH(1-29) fragment with four amino-acid substitutions that resist enzymatic breakdown, almost always injected alongside a GHRP such as ipamorelin to produce a large synchronised GH pulse.
Growth Hormone Secretagogues & GHRH Analogues
Ghrelin
Human trialsThe endogenous 28-amino-acid stomach hormone that every GHRP in this class is imitating, used almost exclusively as a research tool because its short half-life and octanoyl modification make it impractical as a drug.
Growth Hormone Secretagogues & GHRH Analogues
GHRP-1
Human trialsAn early-generation GH-releasing heptapeptide from the same Bowers series as GHRP-6, almost entirely displaced by ipamorelin and GHRP-2 and rarely worth sourcing today.
Growth Hormone Secretagogues & GHRH Analogues
GHRP-2
Approved drugA strong GH-releasing hexapeptide that produces a bigger pulse than ipamorelin, at the cost of moderate appetite stimulation and some cortisol and prolactin drift.
Growth Hormone Secretagogues & GHRH Analogues
GHRP-6
Human trialsThe original GH-releasing peptide, best known now for the ferocious hunger it produces alongside GH release, which makes it useful for hard gainers and unusable during a cut.
Growth Hormone Secretagogues & GHRH Analogues
Hexarelin
Human trialsThe most potent of the classical GH-releasing hexapeptides, with genuinely interesting cardioprotective activity through CD36, but also the fastest to desensitise its own receptor.
Growth Hormone Secretagogues & GHRH Analogues
HGH Fragment 176-191
Animal data onlyThe unmodified lipolytic C-terminal fragment of human growth hormone and the parent of AOD-9604, sold heavily for fat loss on the strength of mouse studies and very little else.
Growth Hormone Secretagogues & GHRH Analogues
Ipamorelin
Human trialsA highly selective pentapeptide ghrelin-receptor agonist that produces a clean growth hormone pulse without meaningfully raising cortisol, prolactin or hunger, which is why it became the default GHRP in modern stacks.
Growth Hormone Secretagogues & GHRH Analogues
Ipamorelin + CJC-1295 blend
AnecdotalThe single most commonly compounded and most widely sold peptide combination, pairing a GHRH analogue with a selective ghrelin-receptor agonist so the two arms of GH control fire together for a much larger pulse than either produces alone.
Growth Hormone Secretagogues & GHRH Analogues
Lonapegsomatropin
Approved drugA weekly growth hormone prodrug in which unmodified somatropin is slowly released from an inert PEG carrier by a self-cleaving linker, so the drug that reaches the receptor is ordinary GH.
Growth Hormone Secretagogues & GHRH Analogues
Macimorelin
Approved drugAn orally active ghrelin-receptor agonist approved specifically as a single-dose diagnostic test for adult growth hormone deficiency, replacing the unpleasant and risky insulin tolerance test.
Growth Hormone Secretagogues & GHRH Analogues
MK-677
Human RCTAn orally bioavailable non-peptide ghrelin mimetic that raises GH and IGF-1 around the clock from a single daily capsule, with appetite, water retention and worsened insulin sensitivity as the standing trade-offs.
Growth Hormone Secretagogues & GHRH Analogues
Sermorelin
Human trialsThe native 29-amino-acid active fragment of human GHRH, and the most clinically established and most commonly physician-prescribed growth hormone secretagogue in the United States.
Growth Hormone Secretagogues & GHRH Analogues
Somapacitan
Approved drugA once-weekly growth hormone analogue that binds reversibly to albumin to stretch a daily injection into a weekly one, approved for both adult and paediatric growth hormone deficiency.
Growth Hormone Secretagogues & GHRH Analogues
Somatrogon
Approved drugA once-weekly growth hormone fusion protein carrying three copies of the hCG C-terminal peptide, which extend its half-life enough to replace daily injections in children with GH deficiency.
Growth Hormone Secretagogues & GHRH Analogues
Somatropin
Approved drugRecombinant 191-amino-acid human growth hormone itself - the reference standard every secretagogue in this class is measured against, and the only one with decades of registration-grade efficacy and safety data.
Growth Hormone Secretagogues & GHRH Analogues
Tabimorelin
Human trialsAn early orally active growth hormone secretagogue from Novo Nordisk that worked but was abandoned when it turned out to inhibit CYP3A4 and raise liver enzymes - historically important, practically obsolete.
Growth Hormone Secretagogues & GHRH Analogues
Tesamorelin
Approved drugThe only FDA-approved GHRH analogue, a stabilised full-length GHRH(1-44) that specifically strips visceral abdominal fat without the appetite or glucose penalties of most fat-loss drugs.
Growth Hormone Secretagogues & GHRH Analogues